期刊
JOURNAL OF INFECTIOUS DISEASES
卷 210, 期 1, 页码 154-157出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu044
关键词
fitness; malaria; Plasmodium; polymorphism; virulence
资金
- International Center of Excellence in Malaria Research grant from National Institutes of Health [AI089674]
- Fogarty International Center training grant from National Institutes of Health [TW007375]
- ACT Consortium through Bill and Melinda Gates Foundation [ITGBVG01]
We explored associations between Plasmodium falciparum drug resistance-mediating polymorphisms and clinical presentations in parasitemic children enrolled in a cross-sectional survey in Tororo, Uganda, using a retrospective case-control design. All 243 febrile children (cases) and 243 randomly selected asymptomatic children (controls) were included. In a multivariate analysis adjusting for age, complexity of infection, and parasite density, the prevalence of wild-type genotypes was significantly higher in febrile children compared to asymptomatic children (pfcrt K76T: odds ratio [OR] 4.41 [95% confidence interval {CI}, 1.28-15.1]; pfmdr1 N86Y: OR 4.08 [95% CI, 2.01-8.31], and pfmdr1 D1246Y: OR 4.90 [95% CI, 1.52-15.8]), suggesting greater virulence for wild-type parasites.
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