4.7 Article

Bacteriophage Therapy of a Vibrio parahaemolyticus Infection Caused by a Multiple-Antibiotic-Resistant O3:K6 Pandemic Clinical Strain

期刊

JOURNAL OF INFECTIOUS DISEASES
卷 210, 期 1, 页码 72-78

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiu059

关键词

Vibrio parahaemolyticus; bacteriophage; pVp-1; pandemic strains

资金

  1. National Research Foundation of Korea - Ministry of Education [2013R1A1A2006794]
  2. National Research Foundation of Korea [2013R1A1A2006794] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Background. Recently isolated Vibrio parahaemolyticus strains have displayed multiple antibiotic resistance. Alternatives to conventional antibiotics are needed, especially for the multiple-antibiotic-resistant V. parahaemolyticus pandemic strain. Methods. A bacteriophage, designated pVp-1, showed effective infectivity for multiple-antibiotic-resistant V. parahaemolyticus and V. vulnificus, including V. parahaemolyticus pandemic strains. The therapeutic potential of the phage was studied in a mouse model of experimental infection using a multiple-antibiotic-resistant V. parahaemolyticus pandemic strain. We monitored the survivability and histopathological changes, quantified the bacterial and phage titers during phage therapy, and observed the immune response induced by phage induction. Results. Phage-treated mice displayed protection from a V. parahaemolyticus infection and survived lethal oral and intraperitoneal bacterial challenges. Conclusions. To the best of our knowledge, this is the first report of phage therapy in a mouse model against a multiple-antibiotic-resistant V. parahaemolyticus pandemic strain infection.

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