期刊
JOURNAL OF INFECTIOUS DISEASES
卷 208, 期 10, 页码 1664-1668出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit348
关键词
influenza; respiratory tract infection; gene expression profiling; RSV; Peptide Chain Initiation; eIF-2 Kinase; microarray analysis; pediatric
资金
- Imperial College Comprehensive Biomedical Research Centre
- Wellcome Trust Centre for Respiratory Infection at Imperial College [DMPED P26077]
- Fondo de Investigacion Sanitaria del plan nacional de I+D+I and 'fondos FEDER (F. I. S.) [PI070069/PI1000540]
- National Institute for Health Research [NF-SI-0611-10230, CL-2007-21-012] Funding Source: researchfish
We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant function distinguishing H1N1/09 patients from controls was protein synthesis, with reduced gene expression. Reduced expression of protein synthesis genes also characterized the H1N1/09 expression profile compared to children with RSV and bacterial infection, suggesting that this is a key component of the pathophysiological response in children hospitalized with H1N1/09 infection.
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