期刊
JOURNAL OF INFECTIOUS DISEASES
卷 208, 期 3, 页码 500-503出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit176
关键词
cerebral malaria; HRP2; malaria diagnostics
资金
- National Institutes of Health [RO1AI34969, K23AI079402]
- University of Washington Housestaff Association
Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据