期刊
JOURNAL OF INFECTIOUS DISEASES
卷 209, 期 2, 页码 236-242出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit590
关键词
animal model; coronavirus; MERS; pathology; rhesus monkey
资金
- National Science and Technology Major Projects of Infectious Disease [2012ZX10004501-004-003, 2012ZX10004501-004-004, 2012ZX1000 4301-8]
- Fundamental Research Funds for the Central Universities [2012Y02, 2012D15]
- Open Fund of the Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health [DWS201214]
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus-Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
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