期刊
JOURNAL OF INFECTIOUS DISEASES
卷 207, 期 8, 页码 1281-1285出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit034
关键词
influenza; viral shedding; infectiousness
资金
- National Institute of Allergy and Infectious Diseases (NIAID) [HHSN266200700005C, ADB N01-AI-70005]
- US Centers for Disease Control and Prevention [1 U01 CI000439]
- Research Fund for the Control of Infectious Disease, Food and Health Bureau, Government of the Hong Kong Special Administrative Region [HK-10-04-02]
- Harvard Center for Communicable Disease Dynamics, from the National Institute of General Medical Sciences [U54 GM088558]
- Area of Excellence Scheme of the Hong Kong University Grants Committee [AoE/M-12/06]
- JST PRESTO program
- F. Hoffmann-La Roche
- Crucell
- MedImmune
Compared with the average transmissibility of human influenza A virus, much less attention has been paid to the potential variability in its transmissibility. We considered viral shedding as a proxy for infectiousness and explored the heterogeneity of infectiousness among patients with medically attended seasonal influenza A virus infection. The analysis revealed that viral shedding is more heterogeneous in children than in adults. The top 20% most infectious children and adults were estimated to be responsible for 89%-96% and 78%-82%, respectively, of the total infectiousness in each age group. Further investigation is required to correlate the substantial variations in viral shedding with heterogeneity in actual transmissibility.
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