期刊
JOURNAL OF INFECTIOUS DISEASES
卷 208, 期 2, 页码 199-202出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit152
关键词
tuberculosis; ibuprofen; active tuberculosis; C3HeB; FeJ mice; bacillary load; survival; tuberculosis treatment; antiinflammatory agents; tuberculosis coadjuvant treatment
资金
- Spanish Government [011/01702]
C3HeB/FeJ mice infected with Mycobacterium tuberculosis were used in an experimental animal model mimicking active tuberculosis in humans to evaluate the effect of antiinflammatory agents. No other treatment but ibuprofen was given, and it was administered when the animals' health started to deteriorate. Animals treated with ibuprofen had statistically significant decreases in the size and number of lung lesions, decreases in the bacillary load, and improvements in survival, compared with findings for untreated animals. Because antiinflammatory agents are already on the market, further clinical trials should be done to evaluate this effect in humans as soon as possible, to determine their suitability as coadjuvant tuberculosis treatment.
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