期刊
JOURNAL OF INFECTIOUS DISEASES
卷 209, 期 9, 页码 1315-1320出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit628
关键词
HIV-1 reservoir; interferon-alpha; ribavirin; HIV-1/HCV coinfection
资金
- Redes Telematicas de Investigacion Cooperativa en Salud (grant RETICS) [Red de SIDA RD12/0017/0029, RD12/0017/0037]
- Fondo de Investigacion Sanitaria [P08/00172, CD10/00382]
- European Molecular Biology Organization
- Massachusetts General Hospital
- US National Institutes of Health [AI093203, AI098487, AI089339]
- Doris Duke Charitable Foundation [2009034]
- American Foundation for AIDS Research [108302-51-RGRL]
Combined treatment with interferon alpha (IFN-alpha) and ribavirin (RBV) can effectively cure HCV infection in a significant proportion of patients, but effects of this regimen on cellular reservoirs for human immunodeficiency virus type 1 (HIV-1) are unknown. Here, we show that treatment with IFN-alpha/RBV led to a moderate but significant and sustained decline of HIV-1 DNA in CD4 T cells from HIV-1/hepatitis C virus-coinfected patients receiving highly active antiretroviral therapy (n = 12). However, in vitro experiments failed to demonstrate an effect of pharmacological doses of IFN-alpha on HIV-1 reactivation. Together, these data suggest that treatment with IFN-alpha/RBV can moderately reduce the reservoir of HIV-1-infected CD4 T cells that persists despite suppressive antiretroviral therapy.
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