期刊
JOURNAL OF INFECTIOUS DISEASES
卷 208, 期 2, 页码 244-248出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jit146
关键词
zidovudine; lamivudine; abacavir; nevirapine; Erythrocebus patas; mesenchymal fibroblasts; micronuclei; centrosomal amplification; aneuploidy
资金
- Intramural Research Program of the Center for Cancer Research, National Cancer Institute, National Institutes of Health
Background. Erythrocebus patas (patas) monkeys were used to model antiretroviral (ARV) drug in human immunodeficiency virus type 1-infected pregnant women. Methods. Pregnant patas dams were given human-equivalent doses of ARVs daily during 50% of gestation. Mesenchymal cells, cultured from bone marrow of patas offspring obtained at birth and at 1 and 3 years of age, were examined for genotoxicity, including centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes. Results. Compared with controls, statistically significant increases (P < .05) in centrosomal amplification, micronuclei, and micronuclei containing whole chromosomes were found in mesenchymal cells from most groups of offspring at the 3 time points. Conclusions. Transplacental nucleoside reverse-transcriptase inhibitor exposures induced fetal genotoxicity that was persistent for 3 years.
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