期刊
JOURNAL OF INFECTIOUS DISEASES
卷 206, 期 10, 页码 1558-1567出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis545
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资金
- National Heart, Lung and Blood Institute [R01 HL095132]
- National Institute of Allergy and Infectious Diseases [AI068634, AI056933]
- UCLA AIDS Institute
- UCLA Center for AIDS Research [AI28697]
- CVD and Metabolic Complications of HIV/AIDS Data Coordinating Center, University of Washington [5R01HL095126]
Background. The relationships between soluble CD14 (sCD14), endotoxin (lipopolysaccharide [LPS]), and progression of atherosclerosis have not been defined in human immunodeficiency virus (HIV) infection. Methods. We retrospectively assessed serum sCD14 and LPS levels of 91 subjects in a prospective 3-year study of carotid artery intima-media thickness (CIMT) (AIDS Clinical Trials Group [ACTG] 5078), where subjects were enrolled as risk factor-controlled triads of HIV-uninfected (n = 36) and HIV-infected individuals with (n = 29) or without (n = 26) protease inhibitor (PI)-based therapy for = 2 years. The primary end point was the yearly rate of change of CIMT (Delta CIMT). Results. In multivariate analysis of the HIV-infected subjects, each 1 mu g/mL above the mean of baseline serum sCD14 corresponded to an additional 1.52 mu m/y (95% confidence interval, .07-2.98; P = .04) in the Delta CIMT. Every 100 pg/mL above the mean of baseline serum LPS corresponded to an additional 0.49 mu m/y (95% confidence interval, .18-.81; P = .003) in the Delta CIMT. However, in univariate analysis in the HIV-uninfected group sCD14 (P = .33) and LPS (P = .27) levels were not associated with higher Delta CIMT. HIV infection and PI therapy were not associated with baseline serum LPS and sCD14 levels (P > .1). Conclusions. Our data are among the first to suggest that serum biomarkers of microbial translocation (LPS) and macrophage activation (sCD14) predict subclinical atherosclerosis progression in HIV-infected persons.
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