期刊
JOURNAL OF INFECTIOUS DISEASES
卷 206, 期 3, 页码 319-323出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis355
关键词
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资金
- Top Institute Pharma, Leiden, the Netherlands
The development of a vaccine against malaria has public health priority. In a controlled setting, preliminary data on the efficacy of Plasmodium falciparum vaccine candidates can be obtained by exposing immunized human volunteers to the bites of laboratory-reared P. falciparum-infected mosquitoes. Using empirical data, we show that these trials, with small numbers of volunteers, are sufficiently powered to detect protective biological effects induced by preerythrocytic and/or blood-stage candidate vaccines if parasitemia is measured daily by quantitative polymerase chain reaction. Sporozoite challenge trials are thus a powerful tool for early selection of candidates that warrant efficacy of trials in the field.
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