期刊
JOURNAL OF INFECTIOUS DISEASES
卷 205, 期 6, 页码 1014-1018出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir884
关键词
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资金
- National Institutes of Health (NIH), National Cancer Institute [P30CA06973, P01CA1539627]
- Howard Hughes Medical Institute
- NIH
- National Institute of Allergy and Infectious Diseases [AI43222]
Identifying cellular reservoirs of human immunodeficiency virus type 1 (HIV-1) in patients on antiretroviral therapy (ART) is critical to finding a cure for HIV-1. In addition to resting CD4(+) T cells, CD34(+) hematopoietic progenitor cells have been proposed as another reservoir. We obtained bone marrow aspirates from 11 patients on ART who had undetectable plasma HIV-1 RNA. HIV-1 DNA was detected in CD4(+) T cells from peripheral blood in all patients and from bone marrow cellular fractions containing T cells in most patients. We did not find HIV-1 DNA in highly purified CD34(+) populations using either a sensitive real-time polymerase chain reaction assay or a coculture assay for replication-competent HIV-1.
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