期刊
JOURNAL OF INFECTIOUS DISEASES
卷 205, 期 2, 页码 194-203出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir715
关键词
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资金
- Division of AIDS, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH)
- US Department of Health and Human Services (DHHS) [U19 AI51794]
- Center for HIV-AIDS Vaccine Immunology via NIAID, NIH
- US DHHS [AI51794]
- Poliomyelitis Research Foundation of South Africa
- Wellcome Trust
- Columbia University
- Fogarty International Center, NIH [D43TW00231]
- South African Medical Research Council
Methods. Inflammatory cytokine concentrations were measured in cervicovaginal lavage (CVL) from 49 women 6, 17, 30, and 55 weeks after HIV-1 infection and from 22 of these women before infection. Associations between genital inflammation and viral load set point and blood CD4 cell counts 12 months after infection were investigated. Results. Elevated genital cytokine concentrations 6 and 17 weeks after HIV-1 infection were associated with higher viral load set points and, to a lesser extent, with CD4 depletion. CVL cytokine concentrations during early infection did not differ relative to preinfection but were elevated in women who had vaginal discharge, detectable HIV-1 RNA in their genital tracts, and lower blood CD4 counts. Conclusion. Genital inflammation during early HIV-1 infection was associated with higher viral load set point and CD4 depletion, which are markers of rapid disease progression. Strategies aimed at reducing genital inflammation during early HIV-1 infection may slow disease progression.
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