期刊
JOURNAL OF INFECTIOUS DISEASES
卷 205, 期 10, 页码 1495-1500出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis236
关键词
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资金
- US National Institutes of Health (NIH) (NIAID [National Institute of Allergy and Infectious Diseases]) [KO8 AI074405, AI074405-03S1, 1K08 AI084546-01]
- Elisabeth Glaser Pediatric AIDS Foundation [MV-00-9-900-1429-0-00]
- MGH/ECOR (Massachusetts General Hospital/Executive Committee on Research)
- Doris Duke Charitable Foundation
- NIH [P30 AI060354]
Regulatory T cells (Tregs) are potent immune modulators, but their role in human immunodeficiency virus type 1 (HIV-1) pathogenesis remains poorly understood. We performed a detailed analysis of the frequency and function of Tregs in a large cohort of HIV-1-infected individuals and HIV-1 negative controls. While HIV elite controllers and uninfected individuals had similar Treg numbers and frequencies, the absolute numbers of Tregs declined in blood and gut-associated lymphoid tissue in patients with chronic progressive HIV-1 infection. Despite quantitative changes in Tregs, HIV-1 infection was not associated with an impairment of ex vivo suppressive function of flow-sorted Tregs in both HIV controllers and untreated chronic progressors.
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