期刊
JOURNAL OF INFECTIOUS DISEASES
卷 207, 期 5, 页码 730-735出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis757
关键词
avian influenza; molecular epidemiology; mathematical modeling
资金
- Impulse Veterinary Avian Influenza Research in the Netherlands program of the Economic Structure Enhancement Fund
Outbreaks of highly pathogenic avian influenza in poultry can cause severe economic damage and represent a public health threat. Development of efficient containment measures requires an understanding of how these influenza viruses are transmitted between farms. However, the actual mechanisms of interfarm transmission are largely unknown. Dispersal of infectious material by wind has been suggested, but never demonstrated, as a possible cause of transmission between farms. Here we provide statistical evidence that the direction of spread of avian influenza A(H7N7) is correlated with the direction of wind at date of infection. Using detailed genetic and epidemiological data, we found the direction of spread by reconstructing the transmission tree for a large outbreak in the Netherlands in 2003. We conservatively estimate the contribution of a possible wind-mediated mechanism to the total amount of spread during this outbreak to be around 18%.
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