期刊
JOURNAL OF INFECTIOUS DISEASES
卷 207, 期 4, 页码 661-665出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis724
关键词
cardiomyopathy; Chagas disease; IL-17; immunoregulation; pathology; T. cruzi; Th17
资金
- National Institutes of Allergy and Infectious Diseases
- National Institutes of Health [AI066044-03]
- Instituto Nacional de Ciencia e Tecnologia- Doencas Tropicais (INCT-DT)
- Fundacao de Amparo'a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
This study was designed to investigate whether the expression of interleukin 17 (IL-17) is associated with the indeterminate or cardiac clinical forms of Chagas disease and whether IL-17 expression can be correlated with patients' cardiac function. Our results demonstrated that cardiac Chagas patients have a lower intensity of expression of IL-17 by total lymphocytes and lower frequency of circulating T helper 17 cells. Correlative analysis showed that high IL-17 expression was associated with better cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Therefore, IL-17 expression can be a protective factor to prevent myocardial damage in human Chagas disease.
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