期刊
JOURNAL OF INFECTIOUS DISEASES
卷 206, 期 11, 页码 1674-1684出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis591
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资金
- US CDC [5U19CI000323-05]
- CDC-Kenya
Background. Although children <5 years old in sub-Saharan Africa are vulnerable to both malaria and influenza, little is known about coinfection. Methods. This retrospective, cross-sectional study in rural western Kenya examined outpatient visits and hospitalizations associated with febrile acute respiratory illness (ARI) during a 2-year period (July 2009-June 2011) in children < 5 years old. Results. Across sites, 45% (149/331) of influenza-positive patients were coinfected with malaria, whereas only 6% (149/2408) of malaria-positive patients were coinfected with influenza. Depending on age, coinfection was present in 4%-8% of outpatient visits and 1%-3% of inpatient admissions for febrile ARI. Children with influenza were less likely than those without to have malaria (risk ratio [RR], 0.57-0.76 across sites and ages), and children with malaria were less likely than those without to have influenza (RR, 0.36-0.63). Among coinfected children aged 24-59 months, hospital length of stay was 2.7 and 2.8 days longer than influenza-only-infected children at the 2 sites, and 1.3 and 3.1 days longer than those with malaria only (all P < .01). Conclusions. Coinfection with malaria and influenza was uncommon but associated with longer hospitalization than single infections among children 24-59 months of age.
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