期刊
JOURNAL OF INFECTIOUS DISEASES
卷 205, 期 8, 页码 1225-1229出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis179
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资金
- National Institutes of Health (NIH) (National Institute on Deafness and Other Communication Disorders (NIDCD) [RO1 08671]
- Sanofi Pasteur
A low level of serum antibody to antigens expressed by Streptococcus pneumoniae has been proposed to explain the susceptibility of children to recurrent episodes of acute otitis media (hereafter, otitis-prone children). By use of enzyme-linked immunospot assays, the percentages of memory B cells to pneumococcal protein antigens PhtD, LytB, PcpA, PhtE, and Ply were compared between otitis-prone and non-otitis-prone children at the time of acute otitis media or nasopharyngeal colonization with S. pneumoniae. We found significantly lower percentages of memory B cells to 3 pneumococcal protein antigens (PhtD, PhtE, and Ply) and reduced antigen-specific immunoglobulin G concentrations in otitis-prone children, compared with non-otitis-prone children.
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