期刊
JOURNAL OF INFECTIOUS DISEASES
卷 205, 期 2, 页码 280-288出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir730
关键词
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资金
- Grand Challenges in Global Health initiative
- Bill & Melinda Gates Foundation
- Foundation for the National Institutes of Health
- Wellcome Trust
- Canadian Institutes of Health Research
- The Native American Research Centers for Health [U26IHS300013/03]
- National Institutes of Health
- Indian Health Service
- Centers for Disease Control and Prevention National Vaccine Program Office
- Thrasher Research Fund
- Pfizer
- Sanofi-Pasteur
- Merck
- Novartis
Methods. Families were enrolled in a carriage study from 2006 to 2008; nasopharyngeal specimens and risk factor information were collected monthly for 7 visits. Pneumococcal carriage prevalence was compared with that before (1998-2000) and during (2001-2002) PCV7 introduction. We compared invasive disease incidence and carriage prevalence before and after PCV7 introduction to estimate changes in serotype-specific invasive potential. Results. We enrolled 1077 subjects from 302 households. There was an absolute reduction in carriage prevalence of 8.0% (95% confidence interval [CI], 4.5%-11.4%) in children aged < 5 years and 3.1% (95% CI, 1.1%-5.1%) in adults. In children aged < 5 years, vaccine-serotype carriage prevalence decreased by 22.8% (95% CI, 20.1%-25.3%), and nonvaccine serotype (NVT) increased by 15.9% (95% CI, 12.4%-19.3%). No significant change was detected in serotype-specific invasive potential after PCV7 introduction. Conclusions. Pneumococcal carriage prevalence decreased in all ages since PCV7 introduction; vaccine-serotype carriage has been nearly eliminated, whereas the prevalence of NVT carriage has increased. The increase in the NVT invasive disease rate seems to be proportional to the increase in colonization prevalence.
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