期刊
JOURNAL OF INFECTIOUS DISEASES
卷 203, 期 2, 页码 258-262出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiq028
关键词
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资金
- US National Institutes of Health [R01 HD 40125, R01 MH 66767, R01 AI23980, R01 AI40951, R01 AI51231]
- Fogarty AIDS International [FIC 2D43 TW001042]
- Emory Center for AIDS Research [P30 AI050409]
Human immunodeficiency virus type 1 (HIV-1)-specific T cell responses were characterized in a blinded study involving infected individuals and their seronegative exposed uninfected (EU) partners from Lusaka, Zambia. HIV-1-specific T cell responses were detected ex vivo in all infected individuals and amplified, on average, 27-fold following in vitro expansion. In contrast, no HIV-1-specific T cell responses were detected in any of the EU partners ex vivo or following in vitro expansion. These data demonstrate that the detection of HIV-1-specific T cell immunity in EU individuals is not universal and that alternative mechanisms may account for protection in these individuals.
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