期刊
JOURNAL OF INFECTIOUS DISEASES
卷 204, 期 7, 页码 1115-1119出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir468
关键词
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资金
- Canadian Institutes for Health Research (CIHR) [230895]
- Fonds de la Recherche en sante du Quebec (FRSQ)
- National Institutes of Health [R01 A1078752]
Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n 5 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (chi(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r(2) = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.
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