期刊
JOURNAL OF INFECTIOUS DISEASES
卷 204, 期 10, 页码 1557-1562出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir616
关键词
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资金
- National Institutes of Health [AI078799, AI074415]
- Doris Duke Charitable Foundation
- Dubai Harvard Foundation for Medical Research
Dendritic cells have critical roles for generating and fine-tuning adaptive immune responses and for regulating immune activity through cytokine secretion. In this study, we analyzed functional properties of dendritic cells in primary human immunodeficiency virus type 1 (HIV-1) infection. We found substantial disarray of the functional properties of myeloid and plasmacytoid dendritic cells in acute HIV-1 infection, which included defective antigen-presenting and cytokine secretion properties and was associated with a distinct surface expression profile of immunomodulatory dendritic cell receptors from the leukocyte immunoglobulin- like receptor family. These data indicate that key functional properties of dendritic cells are compromised during primary HIV-1 infection.
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