期刊
JOURNAL OF INFECTIOUS DISEASES
卷 203, 期 6, 页码 814-822出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiq116
关键词
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资金
- National Institutes of Health [N01-CP-21081, N01-CP-33061, N01-CP-40542, N01-CP-50535, N01-CP-81023, CA78527]
- National Cancer Institute, National Institutes of Health, Department of Health and Human Services
Methods. In a large, population-based natural study conducted in Guanacaste, Costa Rica, we studied a subset of 810 initially HPV-positive women with >= 3 years of active follow-up with >= 3 screening visits who had no future evidence of cervical precancer. Cervical specimens were tested for > 40 HPV genotypes using a MY09/11 L1-targeted polymerase chain reaction method. Results. Seventy-two prevalently-detected HPV infections (5%) in 58 women (7%) persisted until the end of the follow-up period (median duration of follow-up, 7 years) without evidence of cervical precancer. At enrollment, women with long-term persistence were more likely to have multiple prevalently-detected HPV infections (P <.001) than were women who cleared their baseline HPV infections during follow-up. In a logistic regression model, women with long-term persistence were more likely than women who cleared infections to have another newly-detected HPV infection detectable at >= 3 visits (odds ratio, 2.6; 95% confidence interval, 1.2-5.6). Conclusions. Women with long-term persistence of HPV infection appear to be generally more susceptible to other HPV infections, especially longer-lasting infections, than are women who cleared their HPV infections.
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