期刊
JOURNAL OF INFECTIOUS DISEASES
卷 203, 期 11, 页码 1590-1594出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jir145
关键词
-
资金
- Veterans Administration Center on AIDS and HIV infection of the South Texas Veterans Health Care System
- NIH [R37046326]
- VA MERIT award
- Elizabeth Glaser Scientist Award
- Burroughs Wellcome Clinical Scientist Award in Translational Research
- Doris Duke Distinguished Clinical Scientist Award
We investigated the association of polymorphisms in CCR5, the major human immunodeficiency virus (HIV)-1 coreceptor, and copy number of its potent ligand CCL3L1 with tuberculosis in 298 individuals from Colombia. The CCR5-HHD haplotype, a known genetic determinant of increased susceptibility to HIV-AIDS, and a high copy number of CCL3L1, a known genetic determinant of enhanced CCL3/CCL3L1 chemokine expression, each associated with presence of tuberculosis. Furthermore, CCR5-HHD was associated with higher CCR5 gene and surface expression. These results substantiate the strong link between the pro-inflammatory effects of CCR5 and its ligands with active tuberculosis and suggest that chemokine-chemokine receptor genetic determinants may influence tuberculosis in addition to HIV/AIDS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据