期刊
JOURNAL OF INFECTIOUS DISEASES
卷 202, 期 -, 页码 S339-S344出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/655968
关键词
-
资金
- Canadian Institutes for Health Research (CIHR) [HOP-75348, MDP-86721]
- New Investigator Salary Award
- CIHR/International Center for Infectious Diseases National Training Program in Infectious Diseases
- Manitoba Research Chair
- Bill and Melinda Gates Foundation
- University of Manitoba
Studies of human immunodeficiency virus (HIV)-exposed seronegative individuals are crucial to inform vaccine design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce lower levels of proinflammatory cytokines at baseline than HIV-negative control subjects. We also showed that CD4(+) T cells of HIV-exposed seronegative commercial sex workers have a characteristically lower level of gene expression that can be seen in differentially expressed genes and systems crucial for HIV replication, such as the T cell receptor pathway and previously identified HIV dependency factors. This apparent lowered activation results in a phenomenon we term immune quiescence, which may contribute to host resistance to HIV.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据