4.7 Article

The Virologic and Immunologic Effects of Cyclosporine as an Adjunct to Antiretroviral Therapy in Patients Treated during Acute and Early HIV-1 Infection

期刊

JOURNAL OF INFECTIOUS DISEASES
卷 201, 期 9, 页码 1298-1302

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UNIV CHICAGO PRESS
DOI: 10.1086/651664

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  1. National Institutes of Health [AI041534, RR024143, AI43638, AI41531, AI41530, AI-69501, AI 46370, AI 27665, AI069532, M01RR00096, AI 27661]

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Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.

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