期刊
JOURNAL OF INFECTIOUS DISEASES
卷 200, 期 8, 页码 1207-1211出版社
UNIV CHICAGO PRESS
DOI: 10.1086/605930
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资金
- NIAID NIH HHS [R01 AI058736-02, 1U19AI053217, 1U19AI05321, R01 AI066046, U19 AI053217, R01 AI058736, R01 AI054361, U19 AI053217-08, R01 AI54361] Funding Source: Medline
To explore the relationship between human immunodeficiency virus (HIV) and Mycobacterium tuberculosis genotypes, we performed IS6110-based restriction fragment-length polymorphism analysis on M. tuberculosis culture specimens from patients with smear-positive tuberculosis in a periurban community in South Africa from 2001 through 2005. Among 151 isolates, 95 strains were identified within 26 families, with 54% clustering. HIV status was associated with W-Beijing strains (P = .009) but not with clustering per se. The high frequency of clustering suggests ongoing transmission in both HIV-negative and HIV-positive individuals in this community. The strong association between W-Beijing and HIV infection may have important implications for tuberculosis control.
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