期刊
JOURNAL OF INFECTIOUS DISEASES
卷 200, 期 3, 页码 430-438出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/600103
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资金
- ICREA Funding Source: Custom
- CCR NIH HHS [HHSN261200800001C] Funding Source: Medline
- NCI NIH HHS [HHSN261200800001E, R01 CA119903] Funding Source: Medline
- NIAID NIH HHS [U01 AI052142, P30 AI027763] Funding Source: Medline
- NICHD NIH HHS [K01 HD052020, K01 HD052020-03] Funding Source: Medline
- NIMH NIH HHS [T32 MH019105] Funding Source: Medline
Background. Kaposi sarcoma-associated herpesvirus ( KSHV) infection is endemic among adult populations in Africa. A prevailing view is that childhood transmission is primarily responsible for the high seroprevalence of KSHV among adults that is observed throughout the continent. However, few studies have directly examined children, particularly in locations where KS is not commonly endemic. Methods. Participants were children aged 1.5-8.9 years, including 427 children from a population-based sample in South Africa, 422 from a population-based sample in Uganda, and 567 from a clinic-based sample in Uganda. All serum specimens were tested by the same laboratory for KSHV antibodies with use of 2 enzyme immunoassays (against K8.1 and ORF65) and 1 immunofluorescence assay. Results. KSHV seroprevalence was 7.5%-9.0% among South African children and was not associated with age. In contrast, in the Ugandan population-based sample, KSHV seroprevalence increased from 10% among 2-year-old children to 30.6% among 8-year-old children (P-trend <.001). In the Ugandan clinic-based sample, sero-prevalence increased from 9.3% among 2-year-old children to 36.4% among 8-year-old children (P-trend <.001). trend Conclusion. Two distinct relationships between age and KSHV infection among children imply that KSHV transmission among children is not uniform throughout Africa and is therefore not always responsible for the high seroprevalence observed in adults. There are at least 2 patterns of KSHV transmission in Africa.
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