期刊
JOURNAL OF INFECTIOUS DISEASES
卷 200, 期 3, 页码 448-452出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/600072
关键词
-
资金
- NIAID NIH HHS [U19 AI051794, U19 AI051794-05, U19 AI 51794] Funding Source: Medline
- PHS HHS [TWO-0023] Funding Source: Medline
Interleukin (IL)-10 directly inhibits human immunodeficiency virus type 1 (HIV-1) replication, but it may also promote viral persistence by inactivation of effector immune mechanisms. Here, we show in an African cohort that individuals with genotypes associated with high IL-10 production at 2 promoter single-nucleotide polymorphisms (-1082 and -592) were less likely to become HIV-1 infected but had significantly higher median plasma viral loads during the acute phase (<= 3 months after infection). However, as the infection progressed, the association between genotype and median viral load was reversed. Thus, IL-10 may influence HIV-1 susceptibility and pathogenesis, but effects on the latter may differ according to the infection phase.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据