期刊
JOURNAL OF INFECTIOUS DISEASES
卷 200, 期 4, 页码 609-613出版社
UNIV CHICAGO PRESS
DOI: 10.1086/600891
关键词
-
资金
- Intramural NIH HHS [Z99 AI999999] Funding Source: Medline
- NIAID NIH HHS [R01 AI054165-04, R01 AI054165] Funding Source: Medline
Simulation studies were conducted to estimate the statistical power of repeated low-dose challenge experiments performed in nonhuman primates to detect the effect of a candidate human immunodeficiency virus vaccine. The effect of various design parameters on power was explored. Results of simulation studies indicate that repeated low-dose challenge studies with a total sample of size 50 (25 animals/arm) typically provide adequate power to detect a 50% reduction in the per-exposure probability of infection resulting from vaccination. Power generally increases with the maximum number of allowable challenges per animal, the per-exposure risk of infection in control animals, and the proportion of animals susceptible to infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据