期刊
JOURNAL OF INFECTIOUS DISEASES
卷 200, 期 5, 页码 827-831出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/605022
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资金
- Canadian Institutes for Health Research (CIHR)
- Stem Cell and AllerGen Network Centres of Excellence
- Natural Sciences and Engineering Research Council of Canada
- Faculty of Medicine, University of British Columbia
- UBC Centre for Blood Research CIHR/Heart & Stroke Foundation of Canada Strategic Training Program in Transfusion Science
- Michael Smith Foundation for Health Research
In this study, we compared hematopoietic stem cells and mast cells, using microarray expression analysis, and identified the cellular prion protein (PrPC) as a potentially novel marker of mast cells. On further investigation, we found that PrPC is expressed on the surface of human and mouse mast cells, is rapidly released by mast cells upon activation, and is released in response to mast cell-dependent allergic inflammation in vivo. Because mast cells are long lived and traffic to the brain and central nervous system, our observations could have important implications for the transmission and pathology of prion diseases.
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