期刊
JOURNAL OF INFECTIOUS DISEASES
卷 199, 期 6, 页码 815-818出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/597118
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资金
- NIAID NIH HHS [T32AI007140-24] Funding Source: Medline
- PHS HHS [R01-A138383] Funding Source: Medline
Vulvar/vaginal human papillomavirus (HPV) infections may precede cervical infections, and certain low-risk typesmaydisplay vaginal tropism. We evaluated whether incident infections in young women display site-specific preferences by HPV risk group or phylogenetic species. Although incident infections were more likely to be detected in the vulva/vagina than in the cervix (odds ratio, 4.38 [95% confidence interval, 2.51 -7.63]), the majority were first detected at both sites. Low-or undetermined-risk types were more likely than high-risk types to be first detected in the vulva/vagina (P = .03). Site-by-species differences were not statistically significant. Our results suggest that low-or undetermined-risk HPV types preferentially infect vaginal epithelium.
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