期刊
JOURNAL OF INFECTIOUS DISEASES
卷 200, 期 1, 页码 75-78出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/599380
关键词
-
资金
- FIC NIH HHS [D43 TW007127-05, D43 TW007127] Funding Source: Medline
- NIAID NIH HHS [P50 AI030639, P50 AI030639-16, AI-30639] Funding Source: Medline
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL-17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P<.01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r(2) = 0.86; P<.001). These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据