期刊
JOURNAL OF INFECTIOUS DISEASES
卷 197, 期 2, 页码 262-265出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/524691
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资金
- Intramural NIH HHS Funding Source: Medline
West Nile virus (WNV) causes disease in similar to 20% of infected humans. We previously reported that homozygosity for CCR5 Delta 32, a nonfunctional variant of chemokine receptor CCR5, is markedly increased among symptomatic WNV-seropositive patients from Arizona and Colorado. To confirm this, we analyzed cohorts from California and Illinois. An increase in CCR5-deficient subjects was found in both (for California, , lodds ratio [OR], 4.2 [95% confidence interval {CI}, 1.5-11.9] [P= .004]; for Illinois, OR, 3.1 [95% CI, 0.9-11.2] [P = .06]). A meta-analysis of all 4 cohorts showed an OR of 4.2 (95% CI, 2.1-8.3 [P < .0001]). Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.
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