期刊
JOURNAL OF INFECTIOUS DISEASES
卷 198, 期 8, 页码 1175-1179出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/592049
关键词
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资金
- National Sanitarium Association
- Canadian Institutes of Health Research [AHR-81047]
The present study determined whether a pattern of functional single-nucleotide polymorphisms (SNPs) was present that could predispose a Dene cohort to a suboptimal response to Mycobacterium tuberculosis. Compared with a Caucasian cohort, the Dene and Cree were found to maintain a significantly higher frequency of SNPs associated with low expression of vitamin D receptor (VDR), interferon (IFN)-gamma (+874), and tumor necrosis factor-alpha (-308) and high production of monocyte chemoattractant protein (MCP)-1 (-2518) and interleukin (IL)-6 (-174). Given the roles played by IFN-gamma and VDR in facilitating macrophage containment of M. tuberculosis and the opposing role of MCP-1 and IL-6, the observed allelic variation by ethnicity may in part contribute to the high rates of tuberculosis among the Dene.
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