期刊
JOURNAL OF INFECTIOUS DISEASES
卷 198, 期 5, 页码 683-686出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/590430
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资金
- NIAID NIH HHS [K23 AI050449, AI-50449] Funding Source: Medline
- NIDA NIH HHS [DA-016156] Funding Source: Medline
- NIDDK NIH HHS [DK-066939] Funding Source: Medline
Outbreaks of acute hepatitis C virus (HCV) infection are occurring in HIV-infected men who have sex with men. We evaluated risk factors and liver histopathology in 11 consecutively enrolled men with newly acquired HCV infection that was diagnosed on the basis of antibody seroconversion, new elevations in alanine aminotransferase level, and wide fluctuations in HCVRNA level. Ten patients reported unprotected anal intercourse, and 7 reported club-drug use, including methamphetamine. Liver biopsy showed moderately advanced fibrosis (Scheuer stage 2) in 9 patients (82%). No cause of liver damage other than acute HCV infection was identified. The specific pathways leading to periportal fibrosis in HIV-infected men with newly acquired HCV infection require investigation.
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