期刊
JOURNAL OF INFECTIOUS DISEASES
卷 198, 期 8, 页码 1166-1170出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/592053
关键词
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资金
- Intramural Research Program
- National Institute of Allergy and Infectious Diseases (NIAID) [AI52747]
- National Institutes of Health (NIH)
- Division of Microbiology and Infectious Diseases
- National Institute of Child Health and Human Development (NICHD) [K12-HD00850]
Increases in the incidence and severity of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have spawned efforts to define unique virulence properties among prevalent strains. Panton-Valentine leukocidin (PVL), a pore-forming cytotoxin, has garnered attention because of its epidemiologic association with CA-MRSA. Using both the clinical isolate LAC, which is representative of the epidemic USA300 strain, and its isogenic PVL-negative strain in murine models of staphylococcal skin infection and pneumonia, we expanded upon recent studies by assessing the contribution of PVL in the genetic background of BALB/c mice. The data presented in this report support the observation that PVL does not contribute to the pathogenesis of staphylococcal infection of mice.
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