4.7 Article

Acquisition of anal human papillomavirus (HPV) infection in women: the Hawaii HPV cohort study

期刊

JOURNAL OF INFECTIOUS DISEASES
卷 197, 期 7, 页码 957-966

出版社

OXFORD UNIV PRESS INC
DOI: 10.1086/529207

关键词

-

资金

  1. NCI NIH HHS [CA077318] Funding Source: Medline
  2. NCRR NIH HHS [P20 RR11091] Funding Source: Medline

向作者/读者索取更多资源

Background. The majority of anal cancer is associated with human papillomavirus ( HPV) infection, yet little is known about women's risk of acquisition of anal HPV infection. Methods. Risk factors for the acquisition of anal HPV infection were examined in a longitudinal cohort study of 431 women, via repeated measurement of HPV DNA. Results. Seventy percent of women were positive for anal HPV infection at one or more clinic visits from baseline through a follow-up period that averaged 1.3 years. The incidence of a high-risk ( HR) infection was 19.5 ( 95% confidence interval [ CI], 16.0-23.6) per 1000 woman-months. The most common incident HR HPV types were HPV-53, -52 and -16. The presence of an HR anal HPV infection at baseline increased the risk of an incident anal infection by 65%. Baseline HR cervical HPV infection also predicted the acquisition of an HR anal HPV infection ( odds ratio, 1.81 [ 95% CI, 1.09-3.02]). Nonviral risk factors for acquisition of HR HPV infection included younger age, lower socioeconomic status, greater lifetime number of sexual partners, past use of hormones, and condom use. Conclusions. The results of this study suggest that women's risk of anal HPV infection is as common as their risk of cervical HPV infection.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据