期刊
JOURNAL OF INFECTION AND CHEMOTHERAPY
卷 18, 期 4, 页码 555-557出版社
SPRINGER JAPAN KK
DOI: 10.1007/s10156-011-0334-y
关键词
Tuberculosis; Paradoxical reaction; Steroid-refractory; Tumor necrosis factor inhibitor; Adalimumab
We describe a paradoxical response involving the central nervous system in a patient with steroid-refractory tuberculous meningitis that was unresponsive to systemic corticosteroids but was improved with adalimumab. The immunomodulatory effect of tumor necrosis factor inhibitors may have a role in replacing or enhancing the activity of steroids in the management of steroid-refractory tuberculous meningitis.
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