Hypertension, preeclampsia and eclampsia among HIV-infected pregnant women from Latin America and Caribbean countries

Objectives: To evaluate the incidence of and risk factors for hypertensive disorders in a cohort of HIV-infected pregnant women. Methods: Hypertensive disorders ( HD) including preeclampsia/eclampsia (PE/E) and pregnancy induced hypertension, and risk factors were evaluated in a cohort of HIV-infected pregnant women from Latin America and the Caribbean enrolled between 2002 and 2009. Only pregnant women enrolled for the first time in the study and delivered at >= 20 weeks gestation were analyzed. Results: HD were diagnosed in 73 (4.8%, 95% CI: 3.8%-6.0%) of 1513 patients; 35 (47.9%) had PE/E. HD was significantly increased among women with a gestational age-adjusted body mass index (gBMI) >= 25 kg/m(2) (OR = 3.1; 95% CI: 1.9-5.0), hemoglobin (Hg) >= 11 g/dL at delivery (OR = 2.1; 95% CI: 1.2-3.6) and age >= 35 years (OR = 1.8; 95% CI: 1.1-3.2). PE/E was increased among women with a gBMI >= 25 kg/m(2) (OR = 3.0; 95% CI: 1.5-6.0)and Hg >= 11 g/dL at delivery (OR = 2.8; 95% CI: 1.2-6.5). A previous history of PE/E increased the risk of PE/E 6.7 fold (95% CI: 1.8-25.5). HAART before conception was associated with PE/E (OR = 2.3; 95% CI: 1.1-4.9). Conclusions: HIV-infected women, with a previous history of PE/E, a gBMI >= 25 kg/m(2), Hg at delivery >= 11 g/dL and in use of HAART before conception are at an increased risk of developing PE/E during pregnancy. (C) 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.