期刊
JOURNAL OF INFECTION
卷 65, 期 2, 页码 165-172出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2012.04.005
关键词
Prognostic cohort study; Chikungunya infection; Long-term clinical manifestation
资金
- Ministero della Salute Programma Strategico: Zoonosi ed infezioni virali esotiche: fronteggiare le emergenze attraverso un rapporto integrato fra medicina umana e veterinaria. Progetto n. 3. Infezioni da Chikungunya: aspetti epidemiologici e clinici
Objectives: Following a Chikungunya (CHIKV) outbreak in Italy, a cohort study was conducted to describe the infection long-term clinical course and outcome. Methods: Persons identified through active and passive surveillance as confirmed or possible CHIKV cases during the outbreak were enrolled and interviewed by trained public health nurses, between 4-5 and 12-13 months following the acute stage. Patients reporting persistent clinical symptoms were evaluated by rheumatologists. Serum samples were obtained and anti-CHIKV specific IgG and IgM immune responses detected. Only confirmed cases who completed the follow-up were analysed. Results: Out of 250 patients, 66.5% still reported myalgia, asthenia or arthralgia (most frequent sign) after 12 months. Functional ability, measured by the ROAD index, was more impaired for lower extremities (3.75; Inter Quartile Range - IQR 4.4), and the activities of daily living (average 4.2; IQR 5). Variables independently associated with the presence of joint pain at 12-13 months were increasing age, and history of rheumatologic diseases). Elderly, females, and persons with history of rheumatologic diseases had higher anti-CHIKV IgG titres at 12-13 months. Conclusions: This study confirms, in an unselected population, that the long-lasting burden of CHIKV infection is significant. (C) 2012 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据