期刊
JOURNAL OF INFECTION
卷 63, 期 4, 页码 260-266出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2011.04.004
关键词
Influenza; Influenza co-infection; Co-infection; Dual infection; Respiratory virus co-infection; Viral co-infection; Pneumonia; Respiratory disease
资金
- National Institute of Allergy And Infectious Diseases [K23 AI065829]
Objectives: Many patients with influenza have more than one viral agent with co-infection frequencies reported as high as 20%. The impact of respiratory virus copathogens on influenza disease is unclear. We sought to determine if respiratory virus co-infection with pandemic H1N1 altered clinical disease. Methods: Respiratory samples from 229 and 267 patients identified with and without H1N1 influenza respectively were screened for the presence of 13 seasonal respiratory viruses by multiplex RT-PCR. Disease severity between coinfected and monoinfected H1N1 patients were quantified using a standardized clinical severity scale. Influenza viral load was calculated by quantitative RT-PCR. Results: Thirty (13.1%) influenza samples screened positive for the presence of 31 viral copathogens. The most prominent copathogens included rhinovirus (61.3%), and coronaviruses (16.1%). Median clinical severity of both monoinfected and coinfected groups were 1. Patients coinfected with rhinovirus tended to have lower clinical severity (median 0), whereas non-rhinovirus co-infections had substantially higher clinical severity (median 2). No difference in H1N1 viral load was observed between coinfected and monoinfected groups. Conclusions: Respiratory viruses co-infect patients with influenza disease. Patients coinfected with rhinovirus had less severe disease while non-rhinovirus co-infections were associated with substantially higher severity without changes in influenza viral titer. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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