期刊
JOURNAL OF INFECTION
卷 62, 期 4, 页码 292-300出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2011.02.013
关键词
Tuberculosis; Tim-3; CD8 T cells; Functional defects
资金
- National Natural Science Foundation of China [81071318, 81071319, 81061120518]
- Ministry of Health, China [2008ZX10003-012]
Objectives: T cell immunoglobulin and mucin domain-containing molecule 3 (Tim3) plays an important role in regulating T cell responses and induction of peripheral tolerance. In this study, the association of Tim-3 with active pulmonary tuberculosis (TB) was investigated. Methods: Tim-3 expression on CD8 T cells and its influence on production of effector molecules and proliferation of CD8 T cells were examined. Results: Pulmonary TB patients had significantly elevated Tim-3 expression on total CD8 T cells (P < 0.0001) and on antigen-specific CD8 T cells (P = 0.0028) compared with tuberculin-positive healthy controls. The expression of Tim-3 on CD8 T cells was significantly higher in smear/culture-positive TB patients than smear/culture-negative TB patients (P < 0.0001). Tim-3 expressing CD8 T cells had reduced production of IFN-gamma, decreased degranulation and lower proliferation in response to Mycobacterium tuberculosis antigen stimulation. Blocking of Tim-3 signaling led to significantly increased production of IFN-gamma. Conclusions: The elevated expression of Tim-3 on CD8 T cells correlates with functional defects of CD8 T cells and disease severity of pulmonary TB. (c) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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