期刊
JOURNAL OF INFECTION
卷 61, 期 6, 页码 465-470出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2010.08.007
关键词
Listeria monocytogenes; Outbreak; Nosocomial infection; Incubation period; Immunosuppression
资金
- Norwegian Surveillance Programme for Antimicrobial Resistance
- Wyeth
- 3M
- Molnlycke Healthcare
- Amgen
- Roche
- Gilead Sciences
- MSD
Objectives: Listeria monocytogenes is a foodborne pathogen with a high mortality rate. We report a large, nosocomial outbreak of Listeria monocytogenes infection. Methods: Patients with L. monocytogenes isolated from a sterile site, or from faeces when diarrhoea and fever were present, were included. Clinical data were collected from the patient records. The incubation period was calculated as the time between exposure and start of symptoms. Results: Seventeen patients (11 women, median age 64 years) were infected of whom 15 patients were at increased risk for listeriosis. Eleven patients received empiric antibiotic treatment, eight of them with cephalosporins. Three patients died with a resulting mortality rate of 18%. The source of the outbreak was a Camembert cheese made from pasteurised milk containing up to 360 million colony forming units per portion. The median incubation period was 3-4 days. Conclusions: The incubation period in this outbreak was significantly shorter than previously reported, a fact that may be due to the high number of ingested bacteria. Furthermore, food restrictions in hospitals seem warranted, as do treatment with antibiotics effective against L. monocytogenes in at-risk populations. (C) 2010 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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