期刊
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
卷 41, 期 2, 页码 425-431出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-013-1348-5
关键词
Actinomycete; Heterologous host; Secondary metabolite; Natural product biosynthesis
资金
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000607, BBS/E/J/0000A227] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/E/J/00000607, BBS/E/J/0000A227] Funding Source: Medline
Heterologous gene expression is one of the main strategies used to access the full biosynthetic potential of actinomycetes, as well as to study the metabolic pathways of natural product biosynthesis and to create unnatural pathways. Streptomyces coelicolor A3(2) is the most studied member of the actinomycetes, bacteria renowned for their prolific capacity to synthesize a wide range of biologically active specialized metabolites. We review here the use of strains of this species for the heterologous production of structurally diverse actinomycete natural products.
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