期刊
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
卷 35, 期 7, 页码 667-676出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-008-0351-8
关键词
clavulanic acid; cephamycin C; regulation; Streptomyces clavuligerus; ppGpp; pleiotropic regulatory factors; gamma-butyrolactone
Streptomyces clavuligerus produces a large array of natural compounds with antibiotic, antitumor, beta-lactamase inhibition or inmunomodulating activities. The production of cephamycin C, clavulanic acid and other compounds with a clavam structure has been studied for many years. A network of regulatory mechanisms is present in S. clavuligerus to control the formation of different compounds by pathway-specific regulators or pleiotropic regulators. The possible existence of a gamma-butyrolactone signaling system in this streptomycete is emerging. In addition, S. clavuligerus possesses a stringent control mechanism somehow different from those previously reported in other Streptomyces species.
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