期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 20, 期 6, 页码 4371-4376出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2014.02.001
关键词
Characterization; Eggshell; Experimental design; Hyaluronic acid extraction; Sequential optimization strategy
资金
- Iran National Science Foundation (INSF) [88001434]
The optimization of hyaluronic acid (HA) extraction from eggshell was studied by using a sequential experimentation approach. Using the results of factorial experiments, optimization experiments were carried out by response surface methodology. The experimental data as well as the validation tests showed the optimum performance when the extraction pH and time were bounded in the ranges of 3.4-3.5 and 3-3.4 days, respectively, at 9 degrees C. The purified HA was characterized by FTIR spectrum, harmonic mean size and average molecular weight. The study depicted the potential of eggshell as an alternative source for HA extraction to use in industry and medicine. (C) 2014 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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