期刊
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
卷 69, 期 3-4, 页码 303-307出版社
SPRINGER
DOI: 10.1007/s10847-010-9741-4
关键词
Camptothecin; Docetaxel; Idarubicin; Cyclodextrin; Solubility; Isothermal titration calorimetry; Binding constant; Fluorescence anisotropy
The stabilities of the inclusion compounds of three chemotherapeutic agents, camptothecin (CPT), docetaxel (DOC) and idarubicin (IDA), plus a model compound 1,4-dihydroxyanthraquinone (DHA) with several beta-cyclodextrin (beta-CD) derivatives were investigated by solubility measurements, isothermal titration microcalorimetry and fluorescence anisotropy measurements. Ionic heptakis-(6-deoxy-6-thioethers) of beta-CD were found to exhibit very high binding potentials for these drugs making them to good candidates for advanced drug delivery.
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