期刊
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
卷 63, 期 3-4, 页码 219-224出版社
SPRINGER
DOI: 10.1007/s10847-008-9506-5
关键词
Carvedilol; Methyl-beta-cyclodextrin; Phase solubility studies; Characterization; Dissolution
Aim of the present work was to investigate the effect of methyl-beta-cyclodextrin (M beta CD) on the solubility and dissolution rate of carvedilol (CAR), a drug used orally for the treatment of hypertension. Phase solubility studies showed an A(L)-type diagram indicating the formation of inclusion complex in 1:1 molar ratio. Solid binary systems of the drug with M beta CD were prepared by various methods. Physicochemical characterizations were performed using Fourier Transformation Infrared Spectroscopy, Differential Scanning Calorimetry and powder X-Ray Diffractometry. It could be concluded that CAR can form inclusion complex with M beta CD. The dissolution profiles of inclusion complexes were determined and compared with those of CAR alone and the physical mixture. The dissolution rate of CAR was increased by M beta CD inclusion complexation remarkably.
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