期刊
JOURNAL OF IMMUNOLOGY
卷 192, 期 10, 页码 4492-4496出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1303211
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资金
- National Institutes of Health [AI068129, T32 AI007313]
- American Lung Association Senior Research Training Fellowship
CMV induces the expansion of a unique subset of human NK cells expressing high levels of the activating CD94- NKG2C receptor that persist after control of the infection. We investigated whether this subset is CMV specific or is also responsive to acute infection with EBV. We describe a longitudinal study of CMV- and CMV+ students who were acutely infected with EBV. The NKG2C(hi)NK subset was not expanded by EBV infection. However, EBV infection caused a decrease in the absolute number of immature CD56(bright)CD16(-) NK cells in the blood and, in CMV+ individuals, induced an increased frequency of mature CD56(dim)NKG2A(+) CD57(+) NK cells in the blood that persisted into latency. These results provide further evidence that NKG2C(+) NK cells are CMV specific and suggest that EBV infection alters the repertoire of NK cells in the blood.
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